Evidence in support of the Strong Epigenetic Theory of Aging

Epigenetic clocks accurately show your expected remaining lifespan. Sort of like in that In Time movie.

Why am I such a huge fan of epigenetic clocks? Well, because in addition to being the most accurate predictors of our remaining lifespan — better than our passports or any other biomarker — to me they also provide evidence for a hypothesis I consider critical to defeating aging. The hypothesis that aging is an epigenetic program.

These days, most aging researchers agree that epigenetics play an important role in aging, and many, like David Sinclair, go so far as to recognize the role of epigenetics as critical. However, the way David formulates his Information Theory of Aging, the epigenetic…


Staff celebrating the physical completion of the laboratory in 2015, Wuhan, China (Source)

If you hear anyone claim “we know the virus didn’t come from a lab”, don’t buy it — it may well have. Labs around the globe have been creating synthetic viruses like CoV2 for years. And no, its genome would not necessarily contain hallmarks of human manipulation: modern genetic engineering tools permit cutting and pasting genomic fragments without leaving a trace. It can be done quickly, too: it took a Swiss team less than a month to create a synthetic clone of CoV2.

How I Learned to Start Worrying

Oh, come on. Lab-made? Nonsense! Back in January, that was my knee-jerk reaction when ideas that Covid-19…


Not just a copy, but truly still you

When I first heard about the concept of mind uploading, I thought it meant creating a digital copy of one’s mind in a computer where it would then continue to live all on its own. Well, I thought, this is of little comfort to me, the original. Who cares how many of my clones are created, as if I — this particular instance of me — die, it would be the end of the only ‘me’ I have ever been a part of.

To counter that view, some say that a clone of you waking up and believing that it…


What is a biomarker of aging and why do we need it?

We all probably know someone who “looks young for their age” and someone who “hasn’t aged well”:

A biomarker of aging allows us to turn this subjective description into objective medical reality. It enables us to conclusively say: yes, you are 50 years old, but you have the health of a 35-year-old. But you, young man, should take better care of yourself — your biological age is 10 years higher than chronological age, and this is fraught with a 48% increase in the risk of death.

What does aging have to do with the probability of death? Everything. In humans…


Exhumation not needed!

In the past few weeks, many new photographs of both Jeanne and Yvonne have emerged. While none of them offer any conclusive evidence for or against the identity switch, they do add new pieces to the puzzle. Moreover, a brilliant new insight from Philip Gibbs could mean that we can use an existing blood sample of Mme. Calment to conclusively establish whether it belongs to Jeanne or Yvonne. But more on that later.

First, I’d like to share something about Yvonne’s bow hat photo had been bothering me from the start. Take a look, does anything jump out at you?


(Note: To avoid work misattribution, please see the Authorship section at the end of this article)

In part 2 of my series of articles on Jeanne Calment, I wrote that she looks way too young on her ID card photo:

The ID was issued sometime in the 1930s:


(Note: To avoid work misattribution, please see the Authorship section at the end of this article)

If you haven’t read part 1 of the series on Jeanne Calment, it is best to start there.

Update: the ear analysis below is outdated. Please see this article for the current version.

In the comments to my Habr article on Jeanne Calment, user Rikkitik recommended that I look closely at her ears. After all, ear shape or even ear prints have long been used in forensic science for identification. …


(Note: To avoid work misattribution, please see the Authorship section at the end of this article)

For many gerontologists, Jeanne Calment is almost what Joan of Arc is for the French. A symbol, a legend, a saint. The longevity record of Jeanne of Arles, set at 122 years and 164 days, is known to every true aging fighter. Since Jeanne set it in 1997 nobody managed to break it or even get close — the second place barely exceeds 119 years, and the third stands at 117. Of those contenders who stand any chance — i.e. those who are presently…


Диатриба о глупости и привилегированности Трансгуманистического движения

Это мой перевод оригинальной статьи Алекс Пёрлман “The Misguided Idiot’s Quest for Immortality: A diatribe on the folly and privilege of the Transhumanist movement”. Моё мнение не просто не совпадает с мнением автора, а практически прямо ему противоположно.

Трансгуманистическое движение состоит из людей различных политических веяний. Есть те, кто склоняется влево, те, у кого более либертарианское мышление, и есть даже те, кто обладает духом консервативности. Но все они разделяют мнение о том, что наука и техника могут быть использованы для того, чтобы обмануть смерть. И все они витают в облаках.

Я впервые столнулась с Трансгуманизмом в своей работе в качестве…


A diatribe on a diatribe

So you call yourself a bioethicist but don’t even know that aging is Humanity’s biggest killer? Wow, that’s interesting. But seriously, 100,000 people die each day worldwide from age-related causes. If that number doesn’t impress you enough to put on an “Old Lives Matter” t-shirt, I don’t know what would.

What’s that you say? “There is no evidence that personality traits reside within brain tissue”? For real? So which organ, in your view, is responsible for producing that diatribe of yours? Maybe it would be easier to cryopreserve than brain tissues. I know you’ve said that “scientists agree that the…

Yuri Deigin

Life mission: defeat aging. Here I write mostly in English, my Russian articles are on Habr. I am also on Facebook, LinkedIn, YouTube, etc.

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