Yuri Deigin
1 min readJun 29, 2018

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Dear Cheryl,

Thank you for offering your perspective. Certainly, in any statistical distribution, there are outliers. I am glad you find yourself in the good “tail” of the distribution for some aging parameters.

Unfortunately, I cannot agree with you that the decline in any system occurs from disuse. As any professional athlete would attest, the decline is inevitable no matter how hard you train. Disuse can certainly accelerate it, but no amount of use can prevent it. This is true for muscles, heart, lungs, thymus, reproductive system, etc., etc.

I believe that the only way to radically solve the problem of aging and stop our inevitable decline is through genetic engineering. After all, it is DNA that determines whether a given species lives 2 years (mouse), 80 (human), or 200 (whale). Thankfully, science might already know which genes/pathways we should look into to slow down aging and extend our lives:

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Yuri Deigin
Yuri Deigin

Written by Yuri Deigin

Longevity maximalist currently building rejuvenating gene therapies based on in vivo partial cellular reprogramming with Yamanaka factors.

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