Get vaccinated! It could help you, like, not die…

(Everything you ever wanted to know about vax but were afraid to ask)

Vaccines 101

What is the point of a vaccine? To help your body not let the virus get into your cells and start replicating. And even if some of it still manages to get into cells, to speed up the process of your immune system killing those cells. Yes, those infected poor little cells of yours are goners, c’est la vie.

But what if the vaccine kills me?!

Ok, seriously, your chances of dying from Covid itself are much higher than your chances of dying from a vaccine. There have been no vaccine-related deaths reported in clinical trials, and even after 250 MILLION doses have been administered in the US, only ~4500 deaths were reported in VAERS as potentially having any sort of a connection:

The Covid roulette

So what are your chances of catching Covid and then dying from it? Obviously, they greatly depend on your age, as well as where you live, and a few other factors. But let’s just focus on US numbers and do some quick estimations — enough to give us the right orders of magnitude.

But what about Covid vaccines’ long-term safety?

As I said, it would have been great to wait a few years to study the long-term effects of Covid vaccines, but we just don’t have the luxury. Allowing Covid to ravage the planet and potentially develop novel variants while we wait for any potential vaccine long-term effects to manifest themselves is just dumb. This will leave millions more dead (ok, I concede, no unknown long-term issues there) and hundreds of millions Covid survivors susceptible to potential Covid long-term issues. And given a choice between potential long-term issues from Covid or the vaccine, I think the vaccine is a much safer choice.

But the vaccine epitope repertoire sucks! I want MOARE protection, just give me Covid!

Wait, let me get this straight. You prefer to risk dying from Covid for protection against getting it a second time rather than get a vaccine and not risk dying from Covid? That makes zero sense.

What about ADE? Won’t vaccines cause ADE?!

In case you don’t even know what ADE is, it stands for Antibody-dependent enhancement, which is basically when your antibodies turn from friend to foe and instead of preventing the virus from entering your cells, actually help it get in. ADE has been observed in Dengue and HIV and potentially in first SARS, so scientists were rightfully concerned that it might be an issue with SARS2 as well.

But but but Geert said vaccine antibodies will mess up my natural antibodies and prevent them from neutralizing the virus!

Yeah, ok, that is just crazy talk. But yes, that is what Geert Vanden Bossche said:

I heard SARS2 can get into my DNA! Isn’t this a reason to fear vaccines?

Umm, no, this could be a reason to fear SARS2, and want to get vaccinated to not get SARS2, but in no way can this be a reason to fear vaccines.

But don’t vaccines breed new variants?

No! On the contrary, vaccines prevent new variants from appearing. Most of the current novel variants appeared before mass vaccinations have started. So the virus clearly can create novel strains in the absence of vaccine-provided immunity. Moreover, all of the known strains are still neutralized by vaccine-mediated or natural immunity, albeit not as effectively as the original strain. Still, vaccines can protect against them.

But think of the children! How dare you risk their precious lives!

(Disclaimer: climate change is real!)

Ivermectin will save me

Nope. Not by a long shot. Even if you believe the outcome of the severely statistically underpowered clinical trials which show IVM reducing Covid mortality, that mortality risk still remains extremely high: 1.4–3.9% depending on the trial:

I’ll just take my chances

Some young and healthy people think that a 0.1% risk of dying from Covid is negligible, so they shouldn’t even bother getting a vaccine. The problem with that line of reasoning is threefold. First, the anticipated loss in the case of that 0.1% scenario is infinite: you die. A rational person would do anything possible to lower the probability of that happening. Second, if there are many people who think like that, even having 0.1% of them die is unfortunate — they would be dying needlessly. Finally, even if 99.9% of them survive Covid, they could infect many more people whose risks of dying or developing long-term issues from Covid are much higher, and therefore the implied costs of such selfish thinking to society are many times greater than just the loss of life of the selfish 0.1%.

But LNPs will rot my brain!

Vaccines reduce severity of infections even in breakthrough cases

While vaccines can reduce your chances of getting Covid by 10–20 times, they don’t offer perfect protection. Also, you don’t get full protection right away — you actually need two shots for the full Monty, and while a single shot does provide protection, it doesn’t kick in until 2 weeks after the jab. This is why you should still play it safe and not go partying a day after the jab thinking you’re now immune to Covid.

So which vaccine is best?

I like mRNA vaccines — not only do I think that mRNA LNP technology is more ‘pure’ than viral delivery vectors, the mRNA vaccines seem to have the highest safety and efficacy profiles.

But I already had Covid. Should I still get a shot?

This one is a bit tricky, at least at first glance. Obviously, if you just had Covid, you should have plenty of protection against reinfection. The issue is that neutralizing antibodies don’t stick around for too long — in a matter of months their levels greatly decline. So if you catch the virus after that, it will enter your cells, and it will then be up to your T cell immunity to take the brunt of the load of eradicating the virus from your body for the second time.

Vaccinations should be voluntary and with full informed consent

Even though I am a strong vaccine proponent, I am absolutely against any mandatory vaccinations. That just goes against my core principles. I am also not a fan of coercing people into vaccinating. I think it should be done completely voluntarily after all the pros and cons have been examined. At the same time, I think that any reasonable person, after examining all available data, and weighing all those pros and cons, will choose to vaccinate. Because not only does that lower most adults’ chances of dying from Covid by at least 10–20x, if not 100x, but also because vaccines are the key to eradicating Covid altogether.

Funding sources and Conflict of interest statement

This article was sponsored by grant FU0042069420 from the Vaccine Manufacturers Guild, grant FU200133701337 from the EcoHealth Pangolin Malayance, and grant DOS655360B from the Gates 5G Depopulation Foundation.

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Preventing death is my life’s mission. I am a drug developer currently working on a rejuvenating gene therapy using the approach of partial reprogramming.

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Yuri Deigin

Preventing death is my life’s mission. I am a drug developer currently working on a rejuvenating gene therapy using the approach of partial reprogramming.