Reversing Aging: Epigenetic Rejuvenation

Fast-aging (LAKI) Mice

  • lower markers of senescent cells (p16Ink4a and beta-galactosidase)
  • lower marker of double-stranded DNA breaks (gamma-H2AX)
  • lower metalloprotease levels
  • lower interleukin-6 levels
  • lower levels of mitochondrial reactive oxygen species (‘free radicals’)
  • higher number of hair follicles

Normal Mice

Summary

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Yuri Deigin

Yuri Deigin

Preventing death is my life’s mission. I am a drug developer currently working on a rejuvenating gene therapy using the approach of partial reprogramming.